反応 #58351

反応方程式

(±)-cis-6-(3,4-dimethoxyphenyl)-cyclohex-3-enylamine

3,4-bis-cyclopropylmethoxybenzoyl chloride

→

title compound

収率 93.5%

(±)-cis-3,4-Bis-cyclopropylmethoxy-N-[6-(3,4-dimethoxyphenyl)cyclohex-3-enyl]benzamide

収率 93.5%

溶媒

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   抽出After 1 h the reaction mixture is extracted with 2 N hydrochloric acid and water
2. 2
   その他the organic phase is dried
3. 3
   濃縮concentrated

実験手順

20 g of (±)-cis-6-(3,4-dimethoxyphenyl)-cyclohex-3-enylamine (compound G1) are dissolved in 125 ml of dichloromethane and treated with a solution of 24.1 g of 3,4-bis-cyclopropylmethoxybenzoyl chloride in 125 ml of dichloromethane at room temperature. After 1 h the reaction mixture is extracted with 2 N hydrochloric acid and water, the organic phase is dried using sodium sulfate and concentrated. 38.3 g of the title compound of m.p. 152-153.5° C. are obtained.

出典