反応 #58345

反応方程式

(±)-3,4-bis-cyclopropylmethoxy-N-[(1RS,2RS,5RS)-2-(3,4-dimethoxyphenyl)-5-hydroxycyclohexyl]benzamide

compound D1

(±)-3,4-bis-cyclopropylmethoxy-N-[(1RS,2RS,5RS)-2-(3,4-dimethoxyphenyl)-5-hydroxycyclohexyl]benzamide

acetic anhydride

→

title compound

(±)-Acetic acid (1RS,3RS,4RS)-3-{[1-(3,4-bis-cyclopropylmethoxyphenyl)methanoyl]-amino}-4-(3,4-dimethoxyphenyl)cyclohexyl ester

反応条件

後処理

1. 1
   濃縮The solution is concentrated
2. 2
   その他the residue is recrystallized in ethanol

実験手順

3.2 g of (±)-3,4-bis-cyclopropylmethoxy-N-[(1RS,2RS,5RS)-2-(3,4-dimethoxyphenyl)-5-hydroxycyclohexyl]benzamide (compound D1) are dissolved in 70 ml of acetic anhydride and the solution is heated to 100° C. for 5 h. The solution is concentrated and the residue is recrystallized in ethanol. 3.15 g of the title compound of m.p. 148-151° C. are obtained.

出典