反応 #58206

反応方程式

N-[8-(naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]acetamide

hydrochloric acid

sodium hydroxide

→

oily product

収率 94.0%

N-[8-(naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]amine

収率 94.0%

反応条件

後処理

1. 1
   温度The mixture is refluxed for 4 hours
2. 2
   温度cooled in an ice bath
3. 3
   抽出extracted three times with ethyl acetate
4. 4
   洗浄The combined extracts are washed with water and with brine
5. 5
   乾燥dried over anhydrous sodium sulfate
6. 6
   その他evaporated under reduced pressure

実験手順

4 g (12.9 mmol) of N-[8-(naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]acetamide are poured into 13 mL of 5N hydrochloric acid. The mixture is refluxed for 4 hours and then cooled in an ice bath, basified with 35% sodium hydroxide and extracted three times with ethyl acetate. The combined extracts are washed with water and with brine, dried over anhydrous sodium sulfate and then evaporated under reduced pressure. 3.2 g of oily product are obtained (94% yield).

出典