反応 #58183

ord-5baea2d5281d4f12a4851b9d66e69b6a

反応方程式

CC(C)c1cc(O)nc(-c2cccc([N+](=O)[O-])c2)n1
6-isopropyl-2-(3-nitro-phenyl)-pyrimidin-4-ol
CC(C)c1cc(O)nc(-c2cccc([N+](=O)[O-])c2)n1
Intermediate 8
CC(C)c1cc(O)nc(-c2cccc([N+](=O)[O-])c2)n1
6-isopropyl-2-(3-nitro-phenyl)-pyrimidin-4-ol
Fc1ccc(CBr)cc1
4-fluorobenzyl bromide
→
CC(C)c1cc(OCc2ccc(F)cc2)nc(-c2cccc([N+](=O)[O-])c2)n1
title compound
CC(C)c1cc(OCc2ccc(F)cc2)nc(-c2cccc([N+](=O)[O-])c2)n1
4-[(4-Fluorobenzyl)oxy]-6-isopropyl-2-(3-nitrophenyl)pyrimidine

反応物

CC(C)c1cc(O)nc(-c2cccc([N+](=O)[O-])c2)n1
6-isopropyl-2-(3-nitro-phenyl)-pyrimidin-4-ol
CC(C)c1cc(O)nc(-c2cccc([N+](=O)[O-])c2)n1
Intermediate 8
CC(C)c1cc(O)nc(-c2cccc([N+](=O)[O-])c2)n1
6-isopropyl-2-(3-nitro-phenyl)-pyrimidin-4-ol
Fc1ccc(CBr)cc1
4-fluorobenzyl bromide

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The title compound was prepared from 6-isopropyl-2-(3-nitro-phenyl)-pyrimidin-4-ol (which was obtained in Intermediate 8) and 4-fluorobenzyl bromide according to Method A; LC retention time 4.01 min: MS: m/z (ESI) 368 (M+H)

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07423044B2uspto-grants-2008_09