反応 #58140

反応方程式

N,N-bis(2-chloroethyl)amine hydrochloride

benzyl bromide

triethylamine

→

N,N-Bis(2-chloroethyl)benzylamine

溶媒

DMF

反応条件

後処理

1. 1
   その他An ice bath is used
2. 2
   温度to cool
3. 3
   workup.WAITthe mixture is left
4. 4
   濃縮The reaction mixture is concentrated under vacuum
5. 5
   抽出extracted 3 times with ether
6. 6
   乾燥the organic phases are dried over Na2SO4
7. 7
   その他the solvent is evaporated under vacuum

実験手順

An ice bath is used to cool a mixture of 150 g of N,N-bis(2-chloroethyl)amine hydrochloride and 100 ml of benzyl bromide in 1000 ml of DMF and then 120 ml of triethylamine are added dropwise and the mixture is left with stirring at AT overnight. The reaction mixture is concentrated under vacuum, the residue is taken up in water and extracted 3 times with ether, the organic phases are dried over Na2SO4 and the solvent is evaporated under vacuum. This gives 113 g of the expected product.

出典