反応 #58117

反応方程式

5-benzyloxy-8-(2,2-dihydroxy-acetyl)-4H-benzo[1,4]oxazin-3-one

1-(2,6-difluoro-benzyl)-cyclopropylamine

trifluoroacetate

→

8-{2-[1-(2,6-difluoro-benzyl)-cyclopropylamino]-1-hydroxy-ethyl}-5-hydroxy-4H-benzo[1,4]oxazin-3-one

反応条件

後処理

1. 1
   その他Prepared

実験手順

Prepared according to general method 3 from 329 mg (1 mmol) 5-benzyloxy-8-(2,2-dihydroxy-acetyl)-4H-benzo[1,4]oxazin-3-one and 183 mg (1 mmol) 1-(2,6-difluoro-benzyl)-cyclopropylamine. Yield: 108 mg (21%, trifluoroacetate); mass spectroscopy: [M+H]+=391.

出典