反応 #58041

反応方程式

trans-2-(4-tert-Butoxycarbonylamino-cyclohexylmethylene)-succinic acid 4-benzyl ester 1-tert-butyl ester

→

trans-2-(4-tert-Butoxycarbonylamino-cyclohexylmethyl)-succinic acid 1-tert-butyl ester

収率 110.4%

溶媒

ethanol

反応条件

後処理

1. 1
   その他The catalyst was removed from the reaction mixture by filtration
2. 2
   洗浄The catalyst was washed with ethanol
3. 3
   濃縮the solution was concentrated under reduced pressure

実験手順

A solution of trans-2-(4-tert-Butoxycarbonylamino-cyclohexylmethylene)-succinic acid 4-benzyl ester 1-tert-butyl ester (243 mg, 0.51 mmol) and palladium (5% on charcoal) in ethanol (15 mL) was hydrogenated at 4 bar for 3 h. The catalyst was removed from the reaction mixture by filtration. The catalyst was washed with ethanol and the solution was concentrated under reduced pressure to give crude trans-2-(4-tert-Butoxycarbonylamino-cyclohexylmethyl)-succinic acid 1-tert-butyl ester (217 mg, >100%).

出典