反応 #58017

反応方程式

6-bromohexanol

THF

cinnamoyl chloride

→

6-bromohexyl cinnamate

収率 53.0%

溶媒

triethylamine

反応条件

後処理

1. 1
   その他at 0° C
2. 2
   ろ過The resultant was filtered
3. 3
   その他to remove the solvent
4. 4
   その他the residue was purified with a SiO2 column chromatography (EA:n-Hexane=1:5)

実験手順

7 g of 6-bromohexanol was dissolved in a mixed solution of 5 ml of triethylamine as base and 50 ml of THF, and then, cinnamoyl chloride was added dropwise thereto at 0° C. The resultant was filtered to remove the solvent and the residue was purified with a SiO2 column chromatography (EA:n-Hexane=1:5) to obtain 8 g of 6-bromohexyl cinnamate (yield: 53%).

出典