反応 #57999

反応方程式

tert-butylamine

(chloromethyl)trimethylsilane

NaOH

→

title compound 77

N-tert-butyl-N-(trimethylsilylmethyl)amine

反応条件

後処理

1. 1
   温度After cooling to ambient temperature
2. 2
   抽出extracted three times with diethyl ether
3. 3
   洗浄The combined organic extracts were washed with brine
4. 4
   乾燥dried (MgSO4)
5. 5
   その他the volatiles evaporated in vacuo
6. 6
   workup.DISTILLATIONDistillation (atmospheric pressure; ˜135° C.) of the residual liquid

実験手順

A mixture of tert-butylamine (18.0 mL, 171 mmol) and (chloromethyl)trimethylsilane (7.00 g, 57.1 mmol) was heated in a thick-walled glass tube at 200° C. overnight. After cooling to ambient temperature, the reaction mixture was poured into 1 N NaOH and extracted three times with diethyl ether. The combined organic extracts were washed with brine, dried (MgSO4), and the volatiles evaporated in vacuo. Distillation (atmospheric pressure; ˜135° C.) of the residual liquid gave the title compound 77 as a colorless liquid.

出典