反応 #579714

反応方程式

ethyl acetate

6-(2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxy)nicotinamide

K2CO3

1-bromo-3,3-dimethylbutane

→

title compound

6-[2-(3,3-Dimethylbutyl)-2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxy]nicotinamide

溶媒

DMF

反応条件

後処理

1. 1
   温度Cool the reaction mixture to room temperature
2. 2
   洗浄Wash with water (1× 30 mL) and brine (1× 30 mL)
3. 3
   乾燥Dry the organic layer over Na2SO4
4. 4
   ろ過filter
5. 5
   濃縮concentrate
6. 6
   その他Purify by flash chromatography
7. 7
   洗浄eluting with 6% to 15% (2.0 M NH3 in methanol) in ethyl acetate

実験手順

Mix 6-(2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxy)nicotinamide (Example 447, Part E, 0.300 g, 1.06 mmol), K2CO3 (0.366 g, 2.65 mmol), and 1-bromo-3,3-dimethylbutane (0.183 g, 1.11 mmol) in DMF (5.3 mL). Heat at 70° C. overnight. Cool the reaction mixture to room temperature and add ethyl acetate (100 mL). Wash with water (1× 30 mL) and brine (1× 30 mL). Dry the organic layer over Na2SO4, filter and concentrate. Purify by flash chromatography eluting with 6% to 15% (2.0 M NH3 in methanol) in ethyl acetate to give the title compound: MS ES+ 368.2 (M+H)+, HRMS calcd for C22H30N3O2 368.2338 (M+H)+, found 368.2321, time 0.53 min; HPLC [YMC-Pro pack C-18 (150×4.6 mm, S-5 microm), 0.05% TFA/acetonitrile in 0.05% TFA/water at 1.0 mL/min, 10-20% over 5 min, 20-95% over 18 min], tR=11.1 min, 96.8% purity.

出典