反応 #57958

反応方程式

2-{[4-(trifluoromethoxy)benzoyl]amino}-4-{3-[({(1E)-[4-(trifluoromethyl)phenyl]methylidene}amino)oxy]propoxy}benzoic acid methyl ester

methanol

lithium hydroxide

→

4-[3-({[(1E)-1,1′-biphenyl-4-ylmethylidene]amino}oxy)propoxy]-2-{[4-(trifluoromethoxy)benzoyl]amino}benzoic acid

収率 192.8%

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   その他This compound was produced
2. 2
   その他The crude material was crystallized from hot chloroform (10 mL) by the addition of room temperature hexanes (100 mL)
3. 3
   その他The product was isolated
4. 4
   その他triturated with hexanes

実験手順

This compound was produced using similar methods as those used in Step 6, example 28, starting with 2-{[4-(trifluoromethoxy)benzoyl]amino}-4-{3-[({(1E)-[4-(trifluoromethyl)phenyl]methylidene}amino)oxy]propoxy}benzoic acid methyl ester (0.31 g, 0.52 mmol), 1:1 methanol:tetrahydrofuran (10 mL) and 4N aqueous lithium hydroxide solution (0.39 mL). The crude material was crystallized from hot chloroform (10 mL) by the addition of room temperature hexanes (100 mL), and allowing the mixture to sit for 2 hours. The product was isolated and then triturated with hexanes to give 4-[3-({[(1E)-1,1′-biphenyl-4-ylmethylidene]amino}oxy)propoxy]-2-{[4-(trifluoromethoxy)benzoyl]amino}benzoic acid (0.29 g, 97%) as a white solid. mp=187.5-188.5° C. 1H NMR (500 MHz, DMSO-d6); δ 13.47 (bs, 1H), 12.45 (s, 1H), 8.38 (s,2H), 8.04 (d, 2H), 7.99 (d, 1H), 7.81-7.72 (AA′BB′, 4H), 7.58 (d, 2H), 6.80 (d, 1H), 4.34 (t, 2H), 4.20 (t, 2H), 2.18 (m, 2H). Mass spec (MW 570.44); (ES−) m/z 569.39. Elemental analysis; Calculated for C26H20F6N2O6: C, 54.74; H, 3.53; N, 4.91. Found: C, 54.05; H, 3.13; N, 4.80.

出典