反応 #578009

反応方程式

piperidine

3,4,5-trimethoxybenzaldehyde

4-hydroxy-1-methylindole

malononitrile

→

title compound

収率 66.2%

2-Amino-3-cyano-4-(3,4,5-trimethoxyphenyl)-7-methyl-4H-pyrrolo[2,3-h]chromene

収率 66.2%

溶媒

ethanol

反応条件

後処理

1. 1
   その他precipitates
2. 2
   ろ過The precipitates were collected by filtration
3. 3
   その他dried

実験手順

To a mixture of 3,4,5-trimethoxybenzaldehyde (53 mg, 0.27 mmol), 4-hydroxy-1-methylindole (40 mg, 0.27 mmol) and malononitrile (18 mg, 0.27 mmol) in 1.5 mL of ethanol was added piperidine (0.01 ml, 0.1 mmol). The solution was stirred at room temperature overnight and precipitates were observed. The precipitates were collected by filtration and dried to yield 70 mg (66%) of title compound as white solids. 1H NMR (CDCl3): 7.06-7.02 (m, 2H), 6.80 (d, J=8.1 Hz, 1H), 6.57 (d, J=2.4 Hz, 1H), 6.42 (s, 2H), 4.79 (s, 1H), 4.66 (s, 2H), 3.81-3.78 (m, 12H).

出典