反応 #57799

反応方程式

chlorosulfonic acid

4-methyl-5-phenyl-oxazole

→

desired-title compound

4-(4-methyl-oxazol-5-yl)-benzenesulfonyl Chloride

反応条件

後処理

1. 1
   workup.ADDITIONThe reaction mixture was added
2. 2
   抽出the product was extracted with ether (3×50 mL)
3. 3
   抽出The combined organic extract
4. 4
   乾燥was dried over anhydrous Na2SO4 and ether
5. 5
   その他was evaporated
6. 6
   その他The product was purified by flash chromatography (silica-gel, 5-20% ethylacetate/hexane mobile phase)

実験手順

4-methyl-5-phenyl-oxazole (1.6 g, 10 mmol), prepared according to the literature (Heterocycles, 1977, 7, 77-80), was dissolved in chlorosulfonic acid (10 mL) and stirred at room temperature for 4 h. The reaction mixture was added to crushed ice (50 g) and the product was extracted with ether (3×50 mL). The combined organic extract was dried over anhydrous Na2SO4 and ether was evaporated. The product was purified by flash chromatography (silica-gel, 5-20% ethylacetate/hexane mobile phase) to yield 0.91 g of the desired-title compound light yellow solid. MS: m/z 258.0 (M++1).

出典