反応 #577255

反応方程式

19

4-acetamido-N-((4-acetylmorpholin-2-yl)methyl)-2-ethoxybenzamide

N-chlorosuccinimide

→

20

収率 67.4%

4-acetamido-N-((4-acetylmorpholin-2-yl)methyl)-5-chloro-2-ethoxybenzamide

収率 67.4%

溶媒

DMF

反応条件

後処理

1. 1
   濃縮The reaction mixture was then concentrated under reduced pressure to dryness
2. 2
   その他The residue was triturated with H2O
3. 3
   その他the resulting solids were removed by filtration
4. 4
   その他recrystallized from CH3OH

実験手順

A solution of 19 (1.78 g, 4.9 mmol) and N-chlorosuccinimide (0.687 g, 5.1 mmol, 1.05 equiv) in DMF (30 mL) was stirred for 1 h at 70° C. The reaction mixture was then concentrated under reduced pressure to dryness. The residue was triturated with H2O and the resulting solids were removed by filtration and recrystallized from CH3OH to yield 20 (1.314 g).

出典