反応 #577247

反応方程式

4-(2-hydroxy-ethyl)-phenol

potassium carbonate

benzyl bromide

→

2-(4-Benzyloxy-phenyl)-ethanol

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過The reaction mixture is then filtered off trough celite
2. 2
   濃縮concentrated under vacuum

実験手順

To a solution of 4-(2-hydroxy-ethyl)-phenol (50 g, 0.36 mol) in ethanol (400 ml) is added potassium carbonate (75 g, 0.54 mol, 1.5 eq) and benzyl bromide (47.2 ml, 0.39 mol, 1.1 eq), the reaction mixture is stirred at room temperature overnight. The reaction mixture is then filtered off trough celite and concentrated under vacuum. 2-(4-Benzyloxy-phenyl)-ethanol is isolated after crystallization with diethyl ether (82.6 g, 95%).

出典