反応 #577239

反応方程式

benzyl chloroformate

HCl

Benzyl chloroformate

FTY720

HCl

→

(R/S)-4-Hydroxymethyl-4-[2-(4-octyl-phenyl)-ethyl]-oxazolidin-2-one

溶媒

NaOH

反応条件

後処理

1. 1
   workup.WAITThe reaction is kept at RT over night and in order
2. 2
   workup.ADDITIONis added
3. 3
   抽出extracted with methylenechloride
4. 4
   その他purified on a silica gel column

実験手順

Benzyl chloroformate (0.45 ml; 3.2 mmol) is added to a suspension of FTY720.HCl (1.03 g, 3 mmol) in 2N NaOH (20 ml). The reaction is kept at RT over night and in order to complete the reaction further benzyl chloroformate (0.9 ml; 6.4 mmol) is added. After 2 days at RT the reaction is acidified with 1N HCl, extracted with methylenechloride and purified on a silica gel column using methylenechloride/methanol/acetic acid50% (9/1/0.125) as mobile phase.

出典