反応 #577213

反応方程式

4-cyano-4′-hydroxybiphenyl

bromide

potassium carbonate

butanone

→

4-allyloxy-4′-cyanobiphenyl

溶媒

Water

反応条件

後処理

1. 1
   その他A reaction mixture obtained
2. 2
   温度was refluxed for 7 hours
3. 3
   その他was then separated
4. 4
   洗浄An organic layer was washed with water
5. 5
   乾燥dried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off
7. 7
   その他to obtain a residue, which
8. 8
   その他was purified by silica gel column chromatography
9. 9
   その他subjected to recrystallization from ethanol

実験手順

A reaction mixture obtained by adding 20 g of 4-cyano-4′-hydroxybiphenyl, 20 g of ally bromide and 25 g of potassium carbonate to 250 mL of butanone was refluxed for 7 hours. Water was added to the reaction mixture, which was then separated. An organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled off to obtain a residue, which was purified by silica gel column chromatography using toluene as an elusion solvent and then subjected to recrystallization from ethanol to obtain 22 g of 4-allyloxy-4′-cyanobiphenyl.

出典