反応 #57667

反応方程式

5,7-dichloro-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

iodomethane

K2CO3

→

5,7-dichloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

収率 99.3%

溶媒

DMF

反応条件

後処理

1. 1
   洗浄The mixture was washed with brine
2. 2
   抽出extracted with ethyl acetate
3. 3
   洗浄The combined ethyl acetate solution was washed with brine
4. 4
   その他Removal of the solvent in vacuo

実験手順

To 120 mg of 5,7-dichloro-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester was added 1 mL of iodomethane, 200 mg of K2CO3 and 4 mL of DMF. The mixture was stirred at room temperature overnight. The mixture was washed with brine and extracted with ethyl acetate. The combined ethyl acetate solution was washed with brine. Removal of the solvent in vacuo gave 125 mg (99% yield) of 5,7-dichloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester as off-white solid.

出典