反応 #57663

反応方程式

5-chloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

LiOH

→

5-chloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid

収率 87.2%

溶媒

THF

反応条件

後処理

1. 1
   その他The solvents were removed under vacuum
2. 2
   workup.DISSOLUTIONthe residue was dissolved in 5 mL of water
3. 3
   ろ過the resulting suspension was filtered
4. 4
   その他The solid product was triturated with dichloromethane
5. 5
   その他dried under vacuum

実験手順

To 105 mg of 5-chloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester was added 1 mL of THF and 3 mL of LiOH solution (3.6 g LiOH/50 mL MeOH/50 mL H2O). The mixture was stirred at room temperature overnight. The solvents were removed under vacuum and the residue was dissolved in 5 mL of water. The solution was acidified and the resulting suspension was filtered. The solid product was triturated with dichloromethane and dried under vacuum to give 82 mg (87% yield) of 5-chloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid.

出典