反応 #57662

反応方程式

5-chloro-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

iodomethane

K2CO3

→

5-chloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

収率 94.0%

溶媒

DMF

反応条件

後処理

1. 1
   洗浄The mixture was washed with brine
2. 2
   抽出extracted with ethyl acetate
3. 3
   洗浄The combined organic solution was washed with brine and water

実験手順

To 5-chloro-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester (120 mg, 0.47 mmol) was added 0.3 mL (4.7 mmol) of iodomethane, 130 mg (2 eq) of K2CO3 and 4 mL of DMF. The mixture was stirred at room temperature overnight. The mixture was washed with brine and extracted with ethyl acetate. The combined organic solution was washed with brine and water. Removal of the solvent in vacuo gavel 19 mg (94% yield) of 5-chloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester as a white solid.

出典