反応 #57657

反応方程式

5-chloro-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

isopropylbromide

K2CO3

→

5-chloro-4-isopropoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

収率 100.0%

溶媒

DMF

反応条件

後処理

1. 1
   洗浄The mixture was washed with brine
2. 2
   抽出extracted with ethyl acetate
3. 3
   洗浄The combined ethyl acetate layers were washed with brine
4. 4
   その他Removal of the solvent in vacuo

実験手順

To 5-chloro-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester (110 mg) was added 2 mL of isopropylbromide, 150 mg of K2CO3 and 4 mL of DMF. The mixture was stirred at room temperature overnight. The mixture was washed with brine and extracted with ethyl acetate. The combined ethyl acetate layers were washed with brine. Removal of the solvent in vacuo gave 134 mg of 5-chloro-4-isopropoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester as a thick colorless oil (100% yield).

出典