反応 #57625

反応方程式

(S)-2-{4′-[(4-ethoxy-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid methyl ester

LiOH

→

(S)-2-{4′-[(4-ethoxy-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid

収率 91.3%

溶媒

THF

反応条件

後処理

1. 1
   その他The solvents were removed under vacuum
2. 2
   workup.DISSOLUTIONthe residue was dissolved in 5 mL of water
3. 3
   ろ過the resulting suspension was filtered
4. 4
   その他The solid product was dried under vacuum
5. 5
   その他triturated with acetonitrile

実験手順

To 100 mg of (S)-2-{4′-[(4-ethoxy-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid methyl ester dissolved in 1 mL of THF was added 3 mL of LiOH solution (3.6 g LiOH/50 mL MeOH/50 mL H2O). The mixture was stirred at room temperature for 4 days. The solvents were removed under vacuum and the residue was dissolved in 5 mL of water. The solution was acidified and the resulting suspension was filtered. The solid product was dried under vacuum and triturated with acetonitrile to give 89 mg (91% yield) of (S)-2-{4′-[(4-ethoxy-3-methyl-benzofuran-2-carbonyl)-amino]-biphenyl-4-sulfonylamino}-3-methyl-butyric acid as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.8 (dd, J=12.6, 6.6 Hz, 6 H) 1.4 (t, J=6.9 Hz, 3 H) 2.0 (m, 1 H) 2.7 (s, 3 H) 3.6 (m, 1 H) 4.2 (q, J=6.9 Hz, 2 H) 6.8 (d, J=8.3 Hz, 1 H) 7.2 (d, J=8.3 Hz, 1 H) 7.4 (t, J=8.2 Hz, 1 H) 7.8 (d, J=8.8 Hz, 2 H) 7.9 (m, 4 H) 8.0 (d, J=8.8 Hz, 2 H) 8.1 (d, J=9.1 Hz, 1 H) 10.5 (s, 1 H) 12.6 (s, 1 H).

出典