反応 #576

ord-74d98b785957480d946a0d3ab89bccf5

反応方程式

COc1cccc(Br)n1
COc1cccc(Br)n1
C1CC2(CCN1)OCCO2
C1CC2(CCN1)OCCO2
→
COc1cccc(N2CCC3(CC2)OCCO3)n1
COc1cccc(N2CCC3(CC2)
収率 69.1%

反応物

COc1cccc(Br)n1
COc1cccc(Br)n1
C1CC2(CCN1)OCCO2
C1CC2(CCN1)OCCO2

試薬

CC(C)(C)[O-].[Na+]
CC(C)(C)[O-].[Na+]
CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1
CC(C)c1cc(C(C)C)c(-c2ccccc2P(C
CC(=O)O.CC(=O)O.[Pd]
CC(=O)O.CC(=O)O.[Pd]

実験手順

The same procedure as EN03653-93-01.

出典

750 AstraZeneca ELN dataset