反応 #57560

反応方程式

4-bromoaniline

benzofuran-2-carboxylic acid chloride

triethylamine

→

N-(4-bromophenyl)-1-benzofuran-2-carboxamide

収率 82.6%

溶媒

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   温度cooled in ice bath
2. 2
   洗浄The dichloromethane layer was washed with water, 1N HCl, water and brine
3. 3
   乾燥dried over Na2SO4
4. 4
   ろ過filtered
5. 5
   濃縮concentrated in vacuo

実験手順

To 1.72 g of 4-bromoaniline was added to 1.89 g of benzofuran-2-carboxylic acid chloride in 35 mL of dichloromethane cooled in ice bath, followed by the addition of 4.9 mL of triethylamine. The reaction was stirred at room temperature overnight and then diluted with dichloromethane. The dichloromethane layer was washed with water, 1N HCl, water and brine, dried over Na2SO4, filtered, and concentrated in vacuo to provide 2.61 g of N-(4-bromophenyl)-1-benzofuran-2-carboxamide as a yellow solid. Yield 72%. m.p. 178-180° C.; MS: 314.1(M−H)−.

出典