反応 #5748

反応方程式

hydrochloric acid

2-methylthiomethyl-6-methyl-4-(3-nitrophenyl)-3-carboethoxy-5-carboallyloxy-1,4-dihydropyridine

ammonium formate

triphenylphosphine

→

5-carboxy-2-methylthiomethyl-6-methyl-4-(3-nitrophenyl)-3-carboethoxy-1,4-dihydropyridine

溶媒

1,4-dioxane

反応条件

後処理

1. 1
   温度is heated at the reflux temperature for 8 hours
2. 2
   抽出extracted with ethyl acetate (2×20 ml)
3. 3
   洗浄The combined organic extracts are washed with aqueous sodium carbonate (1N; 3×10 l)
4. 4
   その他the basic washings are collected
5. 5
   抽出The resulting suspension is extracted with ethyl acetate (2×25 ml) the combined organic extracts
6. 6
   その他are dried on Na2SO4
7. 7
   その他evaporated under reduced pressure

実験手順

A suspension of 2-methylthiomethyl-6-methyl-4-(3-nitrophenyl)-3-carboethoxy-5-carboallyloxy-1,4-dihydropyridine (g 0.27), palladium on charcoal (10% 6 mg), ammonium formate (mg 71) and triphenylphosphine (mg 3) in anhydrous 1,4-dioxane, is heated at the reflux temperature for 8 hours. The reaction mixture is cooled at room temperature, poured into an aqueous solution of hydrochloric acid (pH=2) and extracted with ethyl acetate (2×20 ml). The combined organic extracts are washed with aqueous sodium carbonate (1N; 3×10 l), the basic washings are collected, acidified to pH 5-6 with diluted aqueous hydrochloric acid. The resulting suspension is extracted with ethyl acetate (2×25 ml) the combined organic extracts are dried on Na2SO4 and evaporated under reduced pressure to give mg 160 of 5-carboxy-2-methylthiomethyl-6-methyl-4-(3-nitrophenyl)-3-carboethoxy-1,4-dihydropyridine as an amorphous solid.

出典