反応 #574138

反応方程式

(6-methyl-1,3-benzodioxol-5-yl)-carboxaldehyde

magnesium ribbon

1-bromopropane

ammonium chloride

→

(6-methyl-1,3-benzodioxol-5-yl)butan-1-ol

収率 88.3%

溶媒

tetrahydrofuran

tetrahydrofuran

反応条件

後処理

1. 1
   抽出The obtained mixture was extracted with ether
2. 2
   洗浄The organic layer was washed with an aqueous solution of common salt
3. 3
   乾燥dried over magnesium sulfate
4. 4
   workup.DISTILLATIONdistilled
5. 5
   その他to remove the solvent

実験手順

A solution of 5.0 g of (6-methyl-1,3-benzodioxol-5-yl)-carboxaldehyde in 20 ml of tetrahydrofuran was dropwise added at a room temperature to a Grignard reagent prepared from 0.86 g of magnesium ribbon, 10 ml of tetrahydrofuran and 4.4 g of 1-bromopropane. The obtained mixture was stirred at a room temperature for one hour, followed by the addition of a saturated aqueous solution of ammonium chloride. The obtained mixture was extracted with ether. The organic layer was washed with an aqueous solution of common salt, dried over magnesium sulfate and distilled to remove the solvent. 5.6 g of (6-methyl-1,3-benzodioxol-5-yl)butan-1-ol was obtained.

出典