反応 #57410

反応方程式

α-Bromo-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

ammonium hydroxide

ammonium hydroxide

→

a-amino-3-hydroxytricyclo[3.3.1.1 3,7]decane-1-acetic acid

反応条件

後処理

1. 1
   濃縮The reaction mixture is then concentrated to a solid
2. 2
   workup.ADDITIONEtOH is then added
3. 3
   濃縮the reaction is again concentrated

実験手順

α-Bromo-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid (Formula Q) is then dissolved in ammonium hydroxide, preferably 30% ammonium hydroxide and the reaction mixture is heated preferably to 65° C. The reaction mixture is then concentrated to a solid. EtOH is then added and the reaction is again concentrated to yield a racemic mixture comprising (<aS)-<a-amino-3-hydroxytricyclo[3.3.1.1 3,7]decane-1-acetic acid (Formula V). See also Example 19 herein.

出典