反応 #574069

反応方程式

HCl

water

2-(4-aminophenoxy)-2-methylpropionic acid

3,5-dichlorophenyl isocyanate

→

2-(4-(3,5-Dichlorophenylureido)phenoxy)-2-methylpropionic acid

溶媒

pyridine

反応条件

後処理

1. 1
   ろ過The precipitate was filtered
2. 2
   洗浄washed several times with cold water
3. 3
   その他dried
4. 4
   その他Recrystallization from aqueous acetone
5. 5
   その他gave small plates 1.81 g (94%) MP 182°-184°

実験手順

To a stirring solution of 4.95 g (0.025 mole) of 2-(4-aminophenoxy)-2-methylpropionic acid in 50 ml dry pyridine, 4.95 g (0.025 mole) of 3,5-dichlorophenyl isocyanate were added. After 1 hour stirring at room temperature, 150 ml water was added and the mixture was acidified with concentrated HCl. The precipitate was filtered, washed several times with cold water and dried. Recrystallization from aqueous acetone gave small plates 1.81 g (94%) MP 182°-184°.

出典