反応 #57397

反応方程式

N-(4-hydroxy-2,3,6-trimethylphenyl)formamide

potassium carbonate

dimethylformamide

1-(3-chloro-2-methyl-1-propenyl)-4-methylbenzene

→

title compound

収率 78.9%

N-[2,3,6-trimethyl-4-[[2-methyl-3-(4-methylphenyl)-2-propenyl]oxy]phenyl]formamide

収率 78.9%

溶媒

Water

toluene

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture was stirred at 30° C. for 1 hr
2. 2
   ろ過The precipitated crystals were collected by filtration
3. 3
   洗浄washed with water and isopropylether

実験手順

To a mixture of N-(4-hydroxy-2,3,6-trimethylphenyl)formamide (660.4 g), potassium carbonate (1019 g) and dimethylformamide (3302 ml) was added a solution of 1-(3-chloro-2-methyl-1-propenyl)-4-methylbenzene (755 g) in toluene (675 ml), and the mixture was stirred at 50° C. for 14 hr. Water (5944 ml) was then added thereto and the mixture was stirred at 30° C. for 1 hr. The precipitated crystals were collected by filtration and washed with water and isopropylether to give the title compound (940 g, yield 74.5%).

出典