反応 #57385

反応方程式

EA

2-aminopyrazine

5-pyridin-2-ylethynyl-thiophene-2-carbaldehyde

tert.-butyl-isonitrile

→

N-tert-butyl-2-(5-(pyridin-2-ylethynyl)thiophen-2-yl)imidazo[1,2-a]pyridin-3-amine

収率 65.0%

溶媒

DCM

chloroform

反応条件

後処理

1. 1
   洗浄Washing
2. 2
   乾燥The mixture was then dried over Na2SO4
3. 3
   ろ過filtered
4. 4
   その他evaporated under a vacuum

実験手順

1.32 g (14.1 mmol) of 2-aminopyrazine were dissolved together with 3.00 g (14.1 mmol) of 5-pyridin-2-ylethynyl-thiophene-2-carbaldehyde, 1.59 ml (14.1 mmol) of tert.-butyl-isonitrile and 2.07 g (4.2 mmol) of scandium(III) trifluoromethanesulfonate in chloroform (40 ml). The reaction solution was heated to 80° C. for 60 min in the microwave (800 watt, MLS-Ethos1600) and then diluted with DCM. Washing was then performed with a 1M Na2CO3 solution and a sat. aq. NaCl solution. The mixture was then dried over Na2SO4, filtered and evaporated under a vacuum. 3.43 g (9.2 mmol, 65%) of N-tert-butyl-2-(5-(pyridin-2-ylethynyl)thiophen-2-yl)imidazo[1,2-a]pyridin-3-amine were obtained by crystallisation of the group from EA.

出典