反応 #57304

反応方程式

2-methoxyphenethylamine

thiophosgene

water

→

(2-methoxyphenethyl)isothiocyanate

収率 71.1%

溶媒

diethylether

反応条件

後処理

1. 1
   抽出The mixture was extracted with diethylether (60 ml)
2. 2
   乾燥dried over anhydrous magnesium sulfate
3. 3
   濃縮concentrated under reduced pressure

実験手順

To a solution of 2-methoxyphenethylamine (1.98 g) in diethylether (20 ml) was added dropwise under ice-cooling thiophosgene (1.54 g). The mixture was stirred at room temperature for 1 hour. To the solution was added water (30 ml). The mixture was extracted with diethylether (60 ml), dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give (2-methoxyphenethyl)isothiocyanate (1.80 g, yield: 71%) as brown oil.

出典