反応 #57302

反応方程式

2-methoxybenzylamine

thiophosgene

water

→

(2-methoxybenzyl)isothiocyanate

収率 99.9%

溶媒

diethylether

反応条件

後処理

1. 1
   抽出extracted with diethylether (60 ml)
2. 2
   乾燥dried over anhydrous magnesium sulfate
3. 3
   濃縮concentrated under reduced pressure

実験手順

To a solution of 2-methoxybenzylamine (1.80 g) in diethylether (20 ml) was added dropwise under ice-cooling for 10 minutes thiophosgene (1.54 g). The mixture was stirred at room temperature for 1 hour. To the reaction solution was added water (30 ml), extracted with diethylether (60 ml), dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give (2-methoxybenzyl)isothiocyanate (2.35 g, yield: 99%) as brown oil.

出典