反応 #5726

反応方程式

methoxymethylchloride

N-(2,6-dichlorobenzoyl)-N'-(4-chlorophenyl)-urea

potassium hydroxide

methyl iodide

→

N-(2,6-dichlorobenzoyl)-N-(methoxymethyl)-N'-(4-chlorophenyl)-urea

溶媒

dimethyl formamide

—

ice water

反応条件

後処理

1. 1
   その他The resulting reaction
2. 2
   その他the solid substance is isolated

実験手順

10.3 g of N-(2,6-dichlorobenzoyl)-N'-(4-chlorophenyl)-urea and 1.88 g of powdered potassium hydroxide (90% are dissolved 40 ml of dimethyl formamide, after which 4.7 of methyl iodide are added drop by drop to the clear solution. The resulting reaction is exothermic. After stirring for two hours the solution is diluted with ice water and the solid substance is isolated. Yield 10.3 g. Melting point 124°-126° C. In a completely similar manner but using methoxymethylchloride instead of methyliodide, N-(2,6-dichlorobenzoyl)-N-(methoxymethyl)-N'-(4-chlorophenyl)-urea is produced. Melting point 121.5°-122.5° C.

出典