反応 #57183

反応方程式

NaOH

N′-(4-{4-(2-{3-[(dimethylamino)methyl]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-[2-(methylamino)ethyl]-1H-pyrazol-3-yl}phenyl)-N,N-dimethylurea

NaOH

Ac2O

→

title compound

収率 90.0%

N-{2-[3-(4-{[(dimethylamino)carbonyl]amino}phenyl)-4-(2-{3-[(dimethylamino)methyl]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-1-yl]ethyl}-N-methylacetamide

収率 90.0%

溶媒

water

MeOH

反応条件

後処理

1. 1
   workup.STIRRINGAfter stirring for 30 min. the reaction
2. 2
   抽出extracted with (9:1) CHCl3/iPrOH
3. 3
   乾燥dried (Na2SO4)
4. 4
   ろ過filtered
5. 5
   その他evaporated to dryness under vacuum
6. 6
   ろ過Trituration with (1:1) Et2O and petroleum ether, filtration
7. 7
   その他drying under vacuum

実験手順

To N′-(4-{4-(2-{3-[(dimethylamino)methyl]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-[2-(methylamino)ethyl]-1H-pyrazol-3-yl}phenyl)-N,N-dimethylurea.3TFA (300 mg, 0.34 mMol) in MeOH (10 mL) was added with stirring at RT, aq. 1 N NaOH and Ac2O (40 uL, 0.42 mMol). After stirring for 30 min. the reaction was diluted with water, basified with aq. 1 N NaOH (0.4 mL), extracted with (9:1) CHCl3/iPrOH, dried (Na2SO4), filtered, and evaporated to dryness under vacuum. Trituration with (1:1) Et2O and petroleum ether, filtration and drying under vacuum gave the title compound (177 mg, 90%) as an off-white solid. ESMS [M+H]+: 579.7.

出典