反応 #57120

ord-d65590b8a5bb4c51bb14a87ecee43459

反応方程式

CN[C@@H]1CCN(CC(c2ccc3ccccc3c2)C2(O)CCCCC2)C1.Cl.Cl
1-[2-[(3R)-3-(methylamino]pyrrolidin-1-yl]-1-(2-naphthyl)ethyl]cyclohexanol dihydrochloride
CC(C)(C)OC(=O)N[C@@H]1CCN(C(=O)C(c2ccc3ccccc3c2)C2(O)CCCCC2)C1
tert-butyl {(3R)-1-[(1-hydroxycyclohexyl)(2-naphthyl)acetyl]pyrrolidin-3-yl}carbamate
→
CN[C@@H]1CCN(CC(c2ccc3ccccc3c2)C2CCCCC2O)C1.Cl.Cl
2-[(3R)-3-(methylamino)pyrrolidin-1-yl-1-(2-naphthyl]ethyl}cyclohexanol Dihydrochloride

反応物

CN[C@@H]1CCN(CC(c2ccc3ccccc3c2)C2(O)CCCCC2)C1.Cl.Cl
1-[2-[(3R)-3-(methylamino]pyrrolidin-1-yl]-1-(2-naphthyl)ethyl]cyclohexanol dihydrochloride
CC(C)(C)OC(=O)N[C@@H]1CCN(C(=O)C(c2ccc3ccccc3c2)C2(O)CCCCC2)C1
tert-butyl {(3R)-1-[(1-hydroxycyclohexyl)(2-naphthyl)acetyl]pyrrolidin-3-yl}carbamate

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

In an analogous manner to Example 13, step 2, 1-[2-[(3R)-3-(methylamino]pyrrolidin-1-yl]-1-(2-naphthyl)ethyl]cyclohexanol dihydrochloride was prepared from tert-butyl {(3R)-1-[(1-hydroxycyclohexyl)(2-naphthyl)acetyl]pyrrolidin-3-yl}carbamate. MS m/z 353; HRMS: calcd for C23H32N2O+H+, 353.25874; found (ESI, [M+H]+), 353.2583.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07419980B2uspto-grants-2008_09