反応 #57053

反応方程式

sodium carbonate

methyl 1-(4-chlorophenyl)cyclobutanecarboxylic acid

sulfuric acid

→

Methyl 1-(4-chlorophenyl)cyclobutanecarboxylate

溶媒

methanol

反応条件

後処理

1. 1
   温度The mixture was refluxed for overnight
2. 2
   その他The solvent was evaporated
3. 3
   workup.DISSOLUTIONThe residue was dissolved in ethyl acetate (50 mL)
4. 4
   洗浄washed with brine (3×10 mL)
5. 5
   乾燥dried over MgSO4
6. 6
   その他The crude product was used for the next reaction without further purification

実験手順

To a solution of methyl 1-(4-chlorophenyl)cyclobutanecarboxylic acid (5.0 g, 23.73 mmol) in anhydrous methanol was added 1 mL of the concentration of sulfuric acid. The mixture was refluxed for overnight. The mixture was neutralized to pH 4-5 with sodium carbonate. The solvent was evaporated. The residue was dissolved in ethyl acetate (50 mL), washed with brine (3×10 mL), dried over MgSO4. The crude product was used for the next reaction without further purification.

出典