反応 #56853

反応方程式

4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine

4-methoxy-phenylamine

→

title compound

収率 61.0%

6-(5-Chloro-2-ethoxy-phenyl)-N*4*-(4-methoxy-phenyl)-pyrimidine-2,4-diamine

収率 61.0%

反応条件

実験手順

Following the method described in Example 53, 4-chloro-6-(5-chloro-2-ethoxy-phenyl)-pyrimidin-2-ylamine and 4-methoxy-phenylamine provided the title compound (61% yield). 1H NMR (DMSO-d6) δ 1.34 (t, 3H, J=6.9 Hz, CH3), 3.74 (s, 3H, CH3), 4.10 (q, 2H, J=7.0 Hz, CH2), 6.18 (s, 2H, NH2), 6.71 (s, 1H, Ar), 6.89 (d, 2H, J=8.6 Hz, Ar), 7.12 (d, 1H, J=8.9 Hz, Ar), 7.39 (dd, 1H, J=8.8 Hz, 2.9 Hz, Ar), 7.53 (d, 2H, J=8.6 Hz, Ar), 7.94 (d, 1H, J=2.8 Hz, Ar), 8.93 (s, 1H, NH).

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