反応 #56844

反応方程式

sodium carbonate

2-amino-4,6-dichloro-5-methyl-pyrimidine

5-chloro-2-methoxy-phenyl boronic acid

triphenylphosphine

→

2-amino-4-chloro-6-(5-chloro-2-methoxyphenyl)-5-methyl-pyrimidine

収率 21.1%

溶媒

glyme

water

反応条件

後処理

1. 1
   ろ過Filtration and concentration of the filtrate
2. 2
   その他yielded a residue which
3. 3
   その他was purified by flash chromatography on silica gel eluting with ethyl acetate-hexane (1:3)

実験手順

To a mixture of 2-amino-4,6-dichloro-5-methyl-pyrimidine (0.18 g, 1.0 mmol), 5-chloro-2-methoxy-phenyl boronic acid (0.19 g, 1.0 mmol), palladium (II) acetate (0.034 g, 0.15 mmol) and triphenylphosphine (0.079 g, 0.30 mmol) was added a solution of sodium carbonate (0.64 g, 6.0 mmol) in water (5 ml) followed by glyme (20 ml). The mixture was stirred under an argon atmosphere at room temperature for 72 hours. Filtration and concentration of the filtrate yielded a residue which was purified by flash chromatography on silica gel eluting with ethyl acetate-hexane (1:3) to provide 2-amino-4-chloro-6-(5-chloro-2-methoxyphenyl)-5-methyl-pyrimidine (0.06 g, 21% yield) as a white powder.

出典