反応 #56819

反応方程式

4-chloro-6-(5-chloro-2-methyl-phenyl)-pyrimidin-2-yl-amine

4-methoxy-phenylamine

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title compound

収率 52.0%

6-(5-Chloro-2-methyl-phenyl)-N*4*-(4-methoxy-phenyl)-pyrimidine-2,4-diamine

収率 52.0%

反応条件

実験手順

Following the method described in Example 26, 4-chloro-6-(5-chloro-2-methyl-phenyl)-pyrimidin-2-yl-amine and 4-methoxy-phenylamine provided the title compound (52% yield). 1H NMR (DMSO-d6) δ 2.34 (s, 3H, CH3), 3.74 (s, 3H, CH3), 6.01 (s, 1H, Ar), 6.28 (s, 2H, NH2), 6.87-6.89 (m, 2H, Ar), 7.30 (d, 1H, J=8.2 Hz, Ar), 7.34-7.39 (m, 2H, Ar), 7.60 (d, 2H, J=8.9 Hz, Ar), 9.01 (s, 1H, NH).

出典