反応 #56805

反応方程式

4,6-dichloro-pyrimidin-2-yl-amine

p-tolylamine

N,N-diisopropylethylamine

→

6-chloro-N*4*-p-tolyl-pyrimidine-2,4-diamine

収率 60.0%

溶媒

ethanol

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度under reflux for 40 hours
3. 3
   ろ過filtration

実験手順

A mixture of 4,6-dichloro-pyrimidin-2-yl-amine (3.3 g, 20 mmol), p-tolylamine (3.4 g, 32 mmol) and N,N-diisopropylethylamine (12 ml) in ethanol (150 ml) was heated under reflux for 40 hours. After cooling to room temperature, filtration provided 6-chloro-N*4*-p-tolyl-pyrimidine-2,4-diamine (2.8 g, 60% yield) as a white solid.

出典