反応 #56782

反応方程式

2-chlorophenylacetic acid

MeOH

→

methyl (2-chlorophenyl)acetate

収率 97.5%

反応条件

後処理

1. 1
   温度the solution was refluxed for 16 hours
2. 2
   濃縮After concentration
3. 3
   洗浄washed with sat'd aq. NaHCO3, H2O and brine
4. 4
   乾燥The organic layer was dried over Na2SO4
5. 5
   濃縮concentrated

実験手順

To 2-chlorophenylacetic acid (1.04 g, 6 mmol) in MeOH (25 mL) was added sulfuric acid (6 drops) and the solution was refluxed for 16 hours. After concentration, the residue was taken up in ethyl acetate and washed with sat'd aq. NaHCO3, H2O and brine. The organic layer was dried over Na2SO4 and concentrated to give methyl (2-chlorophenyl)acetate 6a (1.08 g, 97.5%) as a yellowish oil. GCMS (EI) m/z 184, 186 (M+).

出典