反応 #566726

ord-271c1d1e3c544b26a3059121b44eee03

反応方程式

Cc1ccc(C(N)=O)cc1
p-toluamide
CC(Cl)(Cl)C=O
2,2-dichloropropionaldehyde
c1ccc2[nH]nnc2c1
benzotriazole
Cc1ccc(S(=O)(=O)O)cc1
p-toluenesulfonic acid
→
Cc1ccc(C(=O)NC(n2nnc3ccccc32)C(C)(Cl)Cl)cc1
desired product
Cc1ccc(C(=O)NC(n2nnc3ccccc32)C(C)(Cl)Cl)cc1
N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dichloropropyl]-4-methylbenzamide

反応物

Cc1ccc(C(N)=O)cc1
p-toluamide
CC(Cl)(Cl)C=O
2,2-dichloropropionaldehyde
c1ccc2[nH]nnc2c1
benzotriazole
Cc1ccc(S(=O)(=O)O)cc1
p-toluenesulfonic acid

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

A suspension of p-toluamide, 2,2-dichloropropionaldehyde, benzotriazole, and p-toluenesulfonic acid was processed as described in Example 53A to provide the desired product.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06645968B2uspto-grants-2003_11