反応 #56669

ord-b1de6b841e1b4127b9a7f9a6bff0a0e3

反応方程式

CCN(CC)C(=O)c1ccc([C@H]2CC[C@H](NC(=O)OCc3ccccc3)CC2)cc1
( iii )
CCN(CC)C(=O)c1ccc([C@H]2CC[C@H](NC(=O)OCc3ccccc3)CC2)cc1
trans-4-(4-(N-Benzyloxycarbonylamino)cyclohexyl)-N,N-diethylbenzamide
CCN(CC)C(=O)c1ccc([C@H]2CC[C@H](N)CC2)cc1
( iv )
CCN(CC)C(=O)c1ccc([C@H]2CC[C@H](N)CC2)cc1
trans-4-(4-Aminocyclohexyl)-N,N-diethylbenzamide
CCCCN
n-butylamine
→
CCCCNC(=O)c1ccc([C@H]2CC[C@H](N)CC2)cc1
trans-4-(4-Aminocyclohexyl)-N-butylbenzamide

反応物

CCN(CC)C(=O)c1ccc([C@H]2CC[C@H](NC(=O)OCc3ccccc3)CC2)cc1
( iii )
CCN(CC)C(=O)c1ccc([C@H]2CC[C@H](NC(=O)OCc3ccccc3)CC2)cc1
trans-4-(4-(N-Benzyloxycarbonylamino)cyclohexyl)-N,N-diethylbenzamide
CCN(CC)C(=O)c1ccc([C@H]2CC[C@H](N)CC2)cc1
( iv )
CCN(CC)C(=O)c1ccc([C@H]2CC[C@H](N)CC2)cc1
trans-4-(4-Aminocyclohexyl)-N,N-diethylbenzamide
CCCCN
n-butylamine

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他The compound of the title is obtained

実験手順

The compound of the title is obtained by carrying out the procedure as described in Preparation 8 (iii) and (iv), but using n-butylamine instead of diethylamine.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US07419974B2uspto-grants-2008_09