反応 #56655

反応方程式

3-chloro-2-cyano-2-(2-hydroxyethoxy)propyl acetate

hydroxylamine

→

2-(Chloromethyl)-3-(hydroxyamino)-2-(2-hydroxyethoxy)-3-iminopropyl acetate

溶媒

ethanol

反応条件

後処理

1. 1
   温度The solution was cooled to room temperature
2. 2
   その他in the subsequent reaction

実験手順

A solution of 3-chloro-2-cyano-2-(2-hydroxyethoxy)propyl acetate (9.40 g, 42.4 mmol) in ethanol (150 mL) was treated with 50% aqueous hydroxylamine solution (2.94 g, 44.5 mmol, Aldrich) and the reaction was heated (65° C.) for 1.5 hrs. The solution was cooled to room temperature and the product was used as-is in the subsequent reaction: LC/MS m/z 255.20 (M+H).

出典