反応 #56599

反応方程式

thymidine

triphenylphosphine

→

anhydrothymidine

反応条件

後処理

1. 1
   乾燥azeotropically drying with portions of acetonitrile (MeCN)
2. 2
   温度cooled
3. 3
   workup.ADDITIONis added dropwise to the mixture
4. 4
   workup.ADDITIONThe resulting mixture is treated with water
5. 5
   その他to form a suspension that
6. 6
   ろ過is filtered

実験手順

There are a variety of known techniques for converting a nucleoside into an anhydronucleoside. For example, the anhydronucleoside can be prepared by mixing thymidine with triphenylphosphine and azeotropically drying with portions of acetonitrile (MeCN). The resulting mass is suspended in MeCN and then cooled. The mixture is rapidly stirred and diisopropylazodicarcobxylate in MeCN is added dropwise to the mixture. The resulting mixture is treated with water to form a suspension that is filtered to afford anhydrothymidine. (Grierson, J. R., Shields, A. F., Nuclear Medicine and Biology, 2000, 27 143-156; Balagopala, M. I., Ollapally, A. P., and Lee, H. J., Nucleosides-Nucleotides, 1996, 15(4) 899-906).

出典