反応 #56593

反応方程式

4-hydroxybenzylalcohol

6-iodohexyl acrylate

potassium carbonate

→

4-(6-acryloyloxyhexyloxy)benzylalcohol

溶媒

DMF

反応条件

後処理

1. 1
   温度After being cooled to room temperature the reaction mixture
2. 2
   その他was quenched with 100 ml 3N HCl
3. 3
   抽出extracted with diethylether (2×100 ml)
4. 4
   洗浄The combined ether extracts were washed with saturated NaCl solution
5. 5
   乾燥dried over sodium sulphate
6. 6
   濃縮concentrated to dryness

実験手順

A mixture consisting of 2.48 g of 4-hydroxybenzylalcohol, 5.64 g of 6-iodohexyl acrylate, and 2.76 g of potassium carbonate in 50 ml of DMF was stirred under nitrogen atmosphere for 3 h at 60° C. After being cooled to room temperature the reaction mixture was quenched with 100 ml 3N HCl and extracted with diethylether (2×100 ml). The combined ether extracts were washed with saturated NaCl solution, dried over sodium sulphate and concentrated to dryness to give 5.3 g of nearly pure 4-(6-acryloyloxyhexyloxy)benzylalcohol as a beige heavy oil.

出典