反応 #56591
ord-a770b83f1db64c9a9292a5aa6bd5ee65
反応方程式
sodium bicarbonate
ether
dihydropyrane
6-chlorohexanol
→
product
収率 86.6%
2-(6-Chlorohexyloxy)tetrahydropyrane
収率 86.6%
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1洗浄The ether phase was washed with water
- 2乾燥dried over sodium sulphate
- 3ろ過filtered
- 4濃縮concentrated to dryness
実験手順
To a mixture of 15 g of 6-chlorohexanol, 100 ml of methylenechloride and 0.2 g of p-toluenesulphonic acid were added dropwise 12 g of dihydropyrane in 40 ml of methylenechloride. The reaction mixture was stirred for 15 h at room temperature and then distributed between ether and saturated sodium bicarbonate solution. The ether phase was washed with water, dried over sodium sulphate, filtered and concentrated to dryness. Chromatography of the residue on silica using hexane/ether (3:1) gave 21 g of the product as a colourless oil.