反応 #56590

反応方程式

2-(6-chlorohexyloxy)tetrahydropyrane

hydroquinone

potassiumcarbonate

potassiumiodide

→

product

収率 82.5%

4-(6-(2-Tetrahydropyranyl)oxyhexyloxy)phenol

収率 82.5%

溶媒

dimethylsulfoxide

water

反応条件

後処理

1. 1
   その他to react for 4 days at 80° C
2. 2
   抽出extracted with ether
3. 3
   乾燥The organic phase was then dried over sodium sulphate
4. 4
   ろ過filtered
5. 5
   濃縮concentrated to dryness

実験手順

A mixture of 10 g of 2-(6-chlorohexyloxy)tetrahydropyrane, 25 g of hydroquinone, 31 g of potassiumcarbonate, 0.752 g of potassiumiodide and 250 ml of dimethylsulfoxide was allowed to react for 4 days at 80° C. Subsequently, the reaction mixture was cooled to room temperature and after addition of water extracted with ether. The organic phase was then dried over sodium sulphate, filtered and concentrated to dryness. Chromatography on silica with 10% ethylacetate in toluene gave 11 g of product as a yellowish oil.

出典