反応 #56561

反応方程式

ethyl 2-(2-formylaminothiazol-4-yl)glyoxylate

ethyl 2-(2-formylimino-2,3-dihydrothiazol-4-yl)glyoxylate

sodium hydroxide

→

2-(2-formylaminothiazol-4-yl)glyoxylic acid

溶媒

water

反応条件

後処理

1. 1
   温度ice-cooling
2. 2
   workup.STIRRINGthe mixture was stirred for 5 minutes at 10° to 15° C
3. 3
   ろ過After the reaction mixture was filtered
4. 4
   workup.STIRRINGwith stirring
5. 5
   ろ過The precipitates were collected by filtration
6. 6
   洗浄washed with water
7. 7
   その他dried

実験手順

To a suspension of ethyl 2-(2-formylaminothiazol-4-yl)glyoxylate, which can be represented as ethyl 2-(2-formylimino-2,3-dihydrothiazol-4-yl)glyoxylate, (281 g.) in water (1100 ml.) was added an 1 N sodium hydroxide aqueous solution (2.23 l.) under stirring and ice-cooling, and then the mixture was stirred for 5 minutes at 10° to 15° C. After the reaction mixture was filtered, the filtrate was adjusted to pH 1 with concentrated hydrochloric acid with stirring. The precipitates were collected by filtration, washed with water and then dried to give 2-(2-formylaminothiazol-4-yl)glyoxylic acid, which can be represented as 2-(2-formylimino-2,3-dihydrothiazol-4-yl)glyoxylic acid, (234 g.), mp 133° to 136° C. (dec.).

出典