反応 #56532

反応方程式

a-n-butyl-2,4-dichlorobenzyl cyanide

pyridine

paraformaldehyde

→

2-cyano-2-(2.4-dichlorophenyl)hexan-1-ol

溶媒

benzene triethylammonium hydroxide

反応条件

後処理

1. 1
   workup.ADDITIONis added 1 ml
2. 2
   workup.ADDITIONThe reaction mixture is poured into 300 ml
3. 3
   抽出of water and extracted with ether
4. 4
   洗浄The combined ether extracts are washed with water, saturated sodium chloride solution
5. 5
   乾燥dried over magnesium sulfate
6. 6
   その他The solvent is evaporated
7. 7
   その他to give 5.6g

実験手順

To an ice cold stirred solution of a-n-butyl-2,4-dichlorobenzyl cyanide (5g., 0.02 mole) in 20 ml. of pyridine containing a suspension of paraformaldehyde (2.4g., 0.08 mole) is added 1 ml. of benzene triethylammonium hydroxide. The mixture is stirred under nitrogen at room temperature for 16 hours. The reaction mixture is poured into 300 ml. of water and extracted with ether. The combined ether extracts are washed with water, saturated sodium chloride solution and dried over magnesium sulfate. The solvent is evaporated to give 5.6g. of a thick oil, which is identified by nmr.

出典